Wrapper issues - OpManager will not start

Wrapper issues - OpManager will not start

From wrapper.log

STATUS | wrapper  | 2011/10/17 13:38:25 | --> Wrapper Started as Service
STATUS | wrapper  | 2011/10/17 13:38:26 | Launching a JVM...
INFO   | jvm 1    | 2011/10/17 13:38:28 | WARNING - Unable to load the Wrapper's native library 'wrapper.dll'.
INFO   | jvm 1    | 2011/10/17 13:38:28 |           The file is located on the path at the following location but
INFO   | jvm 1    | 2011/10/17 13:38:28 |           could not be loaded:
INFO   | jvm 1    | 2011/10/17 13:38:28 |             C:\PROGRA~2\MANAGE~1\OPMANA~1\lib\wrapper.dll
INFO   | jvm 1    | 2011/10/17 13:38:28 |           Please verify that the file is readable by the current user
INFO   | jvm 1    | 2011/10/17 13:38:28 |           and that the file has not been corrupted in any way.
INFO   | jvm 1    | 2011/10/17 13:38:28 |           System signals will not be handled correctly.
INFO   | jvm 1    | 2011/10/17 13:38:28 | 
INFO   | jvm 1    | 2011/10/17 13:38:28 | Wrapper (Version 3.1.1) http://wrapper.tanukisoftware.org

This is the only log updated upon a failed start. 

We have seen this in the past, typically a restart of services or reboot of the server resolves it. 

Sometimes, it appears after a DB issue, in which the RepairDB script is run, then a restart of services resolves it.

Forums seem to have seen similar issues, please let me know what else may be required to assist in diagnosing this issue.