Testing the Windows Server 2016 Flash Removal patch 108461 and I get result -2145124329 on all 5 test Windows 2016 datacenter servers.

Go to https://www.catalog.update.microsoft.com/search.aspx?q=4577586

download the 2016 patch named windows10.0-kb4577586-x64_809b9640d04c5af4c7e78499052abaa936cb670a.msu

Run this on 3 of the test servers and get an error: "This version is not applicable to your computer". which matches up with the -2145124329 error from Desktop Central.

So problem looks to be on the Microsoft end?