What's the best way to keep a script/configuration always running?

What's the best way to keep a script/configuration always running?

I have a configuration that uninstalls a piece of software. What i am looking to do is to get it to where any computer that connects to the domain, it will run this configuration. We have already run it against 90% of our domain. But we know certain locations have computers stored away and when they eventually turn them on, we want the configuration to see them and run.

Current configurations seem to stop after only so long.