Sending mail stopped working - Office 365

Sending mail stopped working - Office 365

In trying to research another issue (why is email from helpdesk not being set outside our O365 domain) I accidentally broke our outgoing mail settings, and I cannot put them back.  I took a screenshot of the initial settings, which have been working for months.  I tried changing various parameters and nothing worked to get mail delivered to an outside address, so I gave up.  Now that I've reset everything back as it was, it's not working.  When I try to reply to a ticket it waits about 15 seconds and then creates a popup saying "Sending notification failed."  The O365 Connector is good, didn't change anything there.

Can anyone suggest why this is not working like it used to?  Do I need to restart the server or something?  Is there a log somewhere I can see what exactly it's failing on?  

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