I'm using 10017 but have had this problem for a few previous versions -- it's not common, but occasionally when I click 'send' on a reply the window stays open.
The reply is always sent, and if I put in a status change (e.g. open > resolved) that change is actioned.
I believe it's most likely to happen if the reply window was open for a while - may be related to draft saving?
It's not a big problem for me because it's rare and doesn't seriously interfere with workflow, but I thought it worth mentioning.
Thanks!