MS SQL - Database Tuning Advisor

MS SQL - Database Tuning Advisor

Has anyone run the database engine tuning advisor against the OpManager database in MSSQL? We have run some profile traces, and then put those into the tuning advisor, and it seems to be making a lot of suggestions. What is Adventnets stance on this? Could we do any harm to the database by implementing the recomendations made by the advisor?

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