This policy setting enables programmatic control of Office 365 clients.

If you enable this policy, System Center Configuration Manager or other application management solutions can manage the Office 365 client.  After applying the policy, you will be required to restart the Office Click-to-run service. 

If you disable or do not configure this policy setting, System Center Configuration Manager update workflow will not be able to manage Office 365 clients.  You will, however, be able to continue to use the Office Deployment Tool and System Center Configuration Manager’s program and packages or applications deployment methods. 

Important:  This policy setting only applies to Office 365 clients that are installed by using Click-to-Run, including Office 365 ProPlus, Office 365 Business, Visio Pro for Office 365 and Project Pro for Office 365.  It doesn't apply to Office products that use Windows Installer (MSI)