Error when sending replys

Error when sending replys

The below message just started coming up this morning when trying to reply to tickets.  I checked the email account and everything seems fine, I re-entered my password and get the success message, nothing over the weekend has changed.  I am using Office 365 and it's been working like a champ till now.

Anyone have an idea why all of a sudden without warning it would stop working?

                  New to ADSelfService Plus?