I have a ticket open.  I start writing a reply to the requester.  I go to reference some some more information that is attached to the ticket (for instance, information in the resolution, notes, etc).  I realize I haven't entered the (for instance) resolution yet, and begin doing so.  The open reply window saves my partial reply as a draft which causes the ticket page to refresh.  The page refresh causes me to lose whatever information I've entered into the resolution (or any other field).

Short Description:

The auto-saving of an email causes to page to refresh, which causes any newly (or in progress) information to be lost.