Can I lock a field from editing?

Can I lock a field from editing?

I would like to lock a field from being able to be edited after the request is created...is this possible?  For example, I do not want the user to be able to change the description field.  I have a user who refuses to use the discussion notes but would rather just update the description and keep adding notes.  Management wants notes added.  Can I block them from updating once the request is created?

Thanks
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